Cellular survival over genomic perfection

Evolutionary layering and the limits to cellular perfection.

Although observations from biochemistry and cell biology seemingly illustrate hundreds of examples of exquisite molecular adaptations, the fact that experimental manipulation can often result in improvements in cellular infrastructure raises the question as to what ultimately limits the level of molecular perfection achievable by natural selection. Here, it is argued that random genetic drift c...

Regenerating Perfection.

Molecular and Cellular Pathobiology BCR/ABL Stimulates WRN to Promote Survival and Genomic Instability

BCR/ABL-transformed chronic myeloid leukemia (CML) cells accumulate numerous DNA double-strand breaks (DSB) induced by reactive oxygen species (ROS) and genotoxic agents. To repair these lesions BCR/ABL stimulate unfaithful DSB repair pathways, homologous recombination repair (HRR), nonhomologous endjoining (NHEJ), and single-strand annealing (SSA). Here, we show that BCR/ABL enhances the expre...

Testing perfection is hard

A graph property P is strongly testable if for every fixed > 0 there is a one-sided -tester for P whose query complexity is bounded by a function of . In classifying the strongly testable graph properties, the first author and Shapira showed that any hereditary graph property (such as P the family of perfect graphs) is strongly testable. A property is easily testable if it is strongly testable ...

Profiling, Performance, and Perfection

A profile is “a set of data often in graphic form portraying the significant features of something”. [Web88] Profiles can help us to quickly understand a person or entity better. In the development of computer-based applications, profiles are invaluable. They help us to understand the application – how it works, how well it works, whether it in fact works as we think it does, and whether it is ...